In January 2012, 13 community health centers throughout California received one-year “seed” funding and support to develop innovative ideas, support “out of the box” thinking and test new solutions to common problems in health care. The Center for Care Innovation and Blue Shield of California Foundation engaged Informing Change to conduct an evaluation of this pilot program called the Community Health Center Innovation Challenge. This document highlights key learnings about innovation that were drawn from a larger evaluation of the program. The first section describes the CHCIC program and provides examples of the projects. The second section shares key learnings about engaging in or supporting health care innovation.